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. 2021 Jul 8;11(39):24095–24115. doi: 10.1039/d0ra09250a

Effect of the side chain phenyl on anti-TB activity.

graphic file with name d0ra09250a-u13.jpg
Compound no. R % inhibition 25 μg mL−1 MIC (μg mL−1) ClogP
6b12 graphic file with name d0ra09250a-u14.jpg 99.3% 2.5 3.42
6b13 graphic file with name d0ra09250a-u15.jpg 33.3% NA 2.21
6b14 graphic file with name d0ra09250a-u16.jpg 45.1% NA 3.42
6b15 graphic file with name d0ra09250a-u17.jpg 64.2% NA 3.50
6b16 graphic file with name d0ra09250a-u18.jpg 13.3% NA 2.39
6b17 graphic file with name d0ra09250a-u19.jpg NA NA 2.53
6b18 graphic file with name d0ra09250a-u20.jpg 26.9% NA 2.55
6b19 graphic file with name d0ra09250a-u21.jpg 12.6% NA 2.36
6b20 graphic file with name d0ra09250a-u22.jpg 34.5% NA 3.58
Isoniazid 98.9% 0.25 −0.67