Effect of the side chain phenyl on anti-TB activity.
| ||||
|---|---|---|---|---|
| Compound no. | R | % inhibition 25 μg mL−1 | MIC (μg mL−1) | ClogP |
| 6b12 |
|
99.3% | 2.5 | 3.42 |
| 6b13 |
|
33.3% | NA | 2.21 |
| 6b14 |
|
45.1% | NA | 3.42 |
| 6b15 |
|
64.2% | NA | 3.50 |
| 6b16 |
|
13.3% | NA | 2.39 |
| 6b17 |
|
NA | NA | 2.53 |
| 6b18 |
|
26.9% | NA | 2.55 |
| 6b19 |
|
12.6% | NA | 2.36 |
| 6b20 |
|
34.5% | NA | 3.58 |
| Isoniazid | 98.9% | 0.25 | −0.67 | |