Effect of the linker moiety on the anti-TB activity.
| ||||
|---|---|---|---|---|
| Compound no. | % inhibition 20 μg mL−1 | MIC (μg mL−1) | ClogP | |
| 10a1 |
|
65.7% | NA | 2.91 |
| 10a2 |
|
92.7% | 3.5 | 2.67 |
| 10a3 |
|
NA | NA | 3.5 |
| 10a4 |
|
36.8% | NA | 3.69 |
| 10a5 |
|
99.3% | 20 | 2.96 |
| 10a6 |
|
NA | >50 | 2.32 |
| Isoniazid | 99.4% | 0.25 | −0.67 | |