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. 2022 Apr 25;10:60. doi: 10.1186/s40478-022-01355-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Heart functional and histological evaluation in R-DMDdel52 rats. a ECG signal of (black) control and (red) R-DMDdel52 rat at 6 months of age. b Quantification of the QTpc interval in WT and R-DMDdel52 rats at 3 and 6 months of age. c Hematoxylin and eosin (upper panel) and Sirius red (lower panel) staining of heart of 3-week-old WT and R-DMDdel52 rats (scale bar = 50 μm). d Hematoxylin and eosin (upper panel) and Sirius red (lower panel) staining of heart of WT and R-DMDdel52 rats aged 3 months (scale bar = 50 μm). e Quantification of fibrotic area in the hearts of WT and R-DMDdel52 rats aged 3 weeks and 3 months. f Hematoxylin and eosin (upper panel) and Sirius red (lower panel) staining of heart of WT and R-DMDdel52 rats aged 6 months (scale bar = 50 μm). g Hematoxylin and eosin (upper panel) and Sirius red (lower panel) staining of heart WT and R-DMDdel52 rats aged 12 months (scale bar = 50 μm). h Quantification of fibrotic area in the hearts of WT and R-DMDdel52 rats aged 6 and 12 months