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. 2022 Apr 25;10:60. doi: 10.1186/s40478-022-01355-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Alterations in fat deposition and inflammatory status in R-DMDdel52 diaphragms. a Hematoxylin and eosin staining of TA from WT and R-DMD-del52 rats aged 12 months (scale bar 20 μm). b Lipid droplet staining by Bodipy immunofluorescence (green) on TA of WT and R-DMDdel52 rats aged 3 weeks and 12 months (scale bar 20 μm). Laminin (white) delineates muscle fibres and nuclei are counterstained with Hoechst (blue). c Quantifications of b. d Immunofluorescence for CD68 (green), CD208 (red), and laminin (white) performed on diaphragms isolated from WT and R-DMDdel52 rats aged 6 months. Nuclei were counterstained with Hoechst (blue). Scale bar 10 μm. e Quantification of the number of CD68-positive or CD206-positive macrophages in 3-week-old and 3-, 6-, 12-month-old WT and R-DMDdel52 muscles. f Quantification of the number of CD68-negative and CD206-positive macrophages (CD206⁻:CD68⁺) in 3-week-old and 3-, 6-, 12-month-old WT and R-DMDdel52 muscles