Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 24;19:100. doi: 10.1186/s12974-022-02460-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — ZIKV infection in neurons dysregulates expression of a broad set of genes associated with abnormal or pathologic behavioral states. A Heatmap depicting relative expression values of 181 candidate genes associated with psychiatric disorders. Values are derived from microarray analysis of primary cortical neurons 24 h following ZIKV-MR766 infection (MOI 0.1) or PBS control treatment. B, C Expression values (B) of the top 13 significant differentially expressed genes (DEGs) in our microarray analysis (identified by lowest p values). Table in C lists known functions and associated disorders for these genes. D Descriptive statistics for the curated psychiatric disorder-associated gene list and the significant DEGs observed for each disorder. Data in A and B represent normalized and z-transformed expression values. Data in A include all genes with a False Discovery Rate (FDR) < 0.1