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. 2022 Apr 24;19:100. doi: 10.1186/s12974-022-02460-8

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© The Author(s) 2022

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Fig. 4 — 3-week-old and 8-week-old mice exhibit similar neuroinflammatory responses to intracranial ZIKV infection. A qRT-PCR analysis of ZIKV RNA in the brains of mice at indicated day post-infection (dpi) following intracranial infection with ZIKV-MR766 (10⁴ PFU). Values are reported in plaque forming unit-equivalents (PFUe) per hemisphere of brain tissue. n = 5–7 mice/group. B–K Flow cytometric analysis of infiltrating immune cells in brains of mice at 4dpi following intracranial ZIKV-MR766 infection. B Representative flow cytometry plots showing percentages of infiltrating (CD45^hi) vs. resident (CD45^lo) immune cells. C–G) Quantification of absolute numbers of myeloid cell populations expressing indicated markers. H) Representative flow cytometry plots showing CD45^hi CD3⁺ cells stratified by expression of T cell markers CD4 and CD8. I–K Quantification of absolute numbers of CD45^hi CD3⁺ cell populations expressing indicated markers. n = 3–4 mice/group. * p < 0.05, ** p < 0.01, *** p < 0.001. Bars represent group means