FIG. 2.

Effect of p.o. treatment (twice a day for 5 days beginning 4 h pre-virus exposure) with RWJ-270201 and oseltamivir on SaO₂ decline in influenza A/Shangdong/09/93 (H3N2) virus-infected mice. ■, RWJ-270201, 100 mg/kg/day; ●, RWJ-270201, 10 mg/kg/day; ▴, RWJ-270201, 1 mg/kg/day; ▾, oseltamivir, 10 mg/kg/day; ▸, oseltamivir, 1 mg/kg/day; ⧫, ribavirin, 75 mg/kg/day; □ PSS; ○, normal controls. ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001 (compared to PSS-treated controls). SD, standard deviation.