TABLE 4.
Comparison of the effects of p.o. treatmenta with RWJ-270201, oseltamivir, and ribavirin on influenza B/Hong Kong/05/72 virus infections in mice
| Compound | Dosage (mg/kg/day) | No. of survivors/ totalb | Mean day to deathc ± SDb | Day 11 mean SaO2 (%) ± SDb | Mean lung parameters ± SDb on day 6 (day 3)
|
||
|---|---|---|---|---|---|---|---|
| Score | Wt (mg) | Virus titer (log10/g) | |||||
| RWJ-270201 | 100 | 10/10*** | >21.0 ± 0.0*** | 86.3 ± 2.6*** | 2.4 ± 2.0*** (0.8 ± 0.8**) | 248 ± 26*** (172 ± 24) | 0.0 ± 0.0** (4.0 ± 0.5) |
| 10 | 6/10*** | 10.8 ± 3.4** | 81.8 ± 5.1*** | 2.4 ± 0.2** | 242 ± 43*** | 0.4 ± 0.8* | |
| 1 | 4/10** | 7.5 ± 2.0 | 78.9 ± 5.6** | 2.9 ± 0.7* | 278 ± 76 | 1.8 ± 2.0 | |
| Oseltamivir | 10 | 1/10 | 9.3 ± 1.7** | 78.0 ± 4.1** | 2.3 ± 0.0*** (1.3 ± 1.2) | 232 ± 29*** (166 ± 29*) | 0.4 ± 0.8* (4.4 ± 0.4) |
| 1 | 1/10 | 8.6 ± 1.7* | 76.9 ± 4.2 | 2.4 ± 1.2** | 260 ± 35*** | 2.1 ± 1.7 | |
| Ribavirin | 75 | 9/10*** | 5.0 ± 0.0 | 85.7 ± 4.1*** | 1.6 ± 1.0*** (0.7 ± 0.4***) | 206 ± 53*** (168 ± 24*) | 0.0 ± 0.0** (1.4 ± 1.6***) |
| PSS | 0/19 | 7.1 ± 1.6 | 75.0 ± 0.0 | 3.7 ± 0.4 (1.8 ± 0.4) | 334 ± 28 (202 ± 30) | 3.2 ± 1.5 (3.9 ± 0.6) | |
a
Twice a day for 5 days beginning 4 h pre-virus exposure.
b
*, P < 0.05; **, P < 0.01; ***, P < 0.001 (compared to PSS-treated controls).
c
Animals dying before day 21.