Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 25;20:186. doi: 10.1186/s12967-022-03393-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — Experimental verification of the relationship between PLTP and prognosis and immune microenvironment in the DLBCL TMA cohort. A Kaplan–Meier curve for the PLTP high- and low- expression groups in our TMA cohort. The optimal cutoff point was obtained from X-tile 3.6.1 software. B Characterization of cell immunophenotypes with mIHC. A staining panel was developed to visualize DAPI, CD68, CD163 and PLTP simultaneously on the same tissue slide. C M2 macrophages content in the PLTP high- and low-expression groups. CD68+CD163+ indicated the content of M2 macrophages (p value by Wilcoxon rank-sum test). D Characterization of cell immunophenotypes with mIHC. A staining panel was developed to visualize DAPI, CD11B and PLTP simultaneously on the same tissue slide. E TAMs content in the PLTP high- and low- expression groups. CD11B+ indicated the content of TAMs (p value by Wilcoxon rank-sum test). F Characterization of cell immunophenotypes with mIHC. A staining panel was developed to visualize DAPI, PD-1, PD-L1, LAG3 and PLTP simultaneously on the same tissue slide. CD274 indicated the content of PD-L1 and PDCD1 indicated the content of PD-1. G–I Correlations between PLTP expression and immune checkpoints (including PD-1, PD-L1, and LAG3)