. 2022 Apr 25;22:113. doi: 10.1186/s12866-022-02532-y

Table 2.

Characteristics of K. pneumoniae ST14/15 strains with respect to presence of genes associated with increased silver tolerance

						Mode MIC/MBC (mg/L)
Strain	ST	sil operon	cus operon	ompC^a	ompF	Silver Nitrate (AgNO₃)		Silver Sulfadiazine (AgSD)
						MIC	MBC	MIC	MBC
NCTC 13443	14	Yes	Yes	GD insertion	Tn disrupted	16–32	64	32–64	128
KPUK04a	14	Yes	Yes	GD insertion		16–32	64	64–128	128–256
KPUK04b	14	Yes	Yes			16–32	64	32	128–256
KPTR8	14	Yes	Yes			32	32–64	64	128–256
CFI_001_VIM1	14	Yes (Poss IS1 Tn insertion in silF)	Yes	Tn in promoter		64	64	128	256
CFI_111_OXA232	14	No	Yes	GD insertion		32	32–64	256	256
CFI_112_NDM1	14	Yes	Yes	L290R		64–128	128	128–256	256
CFI_124_NDM1OXA232	14	No	Yes		1 bp insertion after n622	16	32–64	64	128–256
CFI_128_NDM1	14	No	Yes	GD insertion		32	32–64	256	256
CFI_133_OXA484	14	No	Yes	GD insertion	W230STOP	32	32–64	256	128–256
CFI_146_OXA48	14	Yes	Yes			64	64	128	128–256
KPUK01	15	Yes	Yes	Tn in promoter	Y242STOP	8	32	16	64
18	15	Yes	Yes			16	32–64	64	256
CFI_005_VIM4	15	No	Yes		Tn disrupted	16	32–64	128	128–256
CFI_006_VIM4	15	No	Yes		Tn disrupted	16	32	128	256
CFI_014_VIM4	15	Yes	Yes		Tn disrupted	16	64	32	128–256
CFI_086_VIM2	15	No	Yes		Tn disrupted	32	64	128	128–256
CFI_104_VIM2	15	No	Yes		Tn disrupted	32	32–64	128	256
CFI_123_NDM1OXA232	15	Yes	Yes			>512	>512	>512	>512
CFI_132_OXA48	15	Yes	Yes		Tn disrupted	64	64	256	128–256
CFI_134_NDM1	15	No	Yes		Tn disrupted	16	32–64	32–64	64
CFI_139_KPC2	15	No	Yes			16	32–64	128	128–256
CFI_145_NDM1	15	Yes (Poss IS5 Tn insertion in silB)	Yes			8–16	16–64	32	32–64

^aGD insertion occurs after amino acid 135 and is thought to restrict the pore size for OmpC