Substituent effect of 2-pyridone catalyst.
| |||
|---|---|---|---|
| Entry | R | Conversiona | |
| 1 |
|
NO2 (10a) | 23% |
| 2 | Cl (10b) | 27% | |
| 3 | OMe (10c) | 34% | |
| 4 |
|
CF3 (11a) | 32% |
| 5 | Cl (11b) | 37% | |
| 6 | OMe (11c) | 34% | |
| 7 |
|
NO2 (12a) | 42% |
| 8 | Cl (12b) | 51% | |
| 9 | OMe (12c) | 41% | |
| 10 |
|
Cl (13a) | 81% |
| 11 | Br (13b) | 78% | |
| 12 | I (13c) | 86% | |
| 13 | F (13d) | 31% | |
| 14 | CO2Me (13e) | 50% | |
| 15 | OMe (13f) | 52% | |
| 16 | CH3 (13g) | 34% | |
| 17 |
|
Cl (14a) | 58% |
| 18 | NO2 (14b) | 22% | |
Conversion was calculated by 1H NMR spectroscopy.