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. 2021 Jul 14;11(40):24588–24593. doi: 10.1039/d1ra04651a

Substituent effect of 2-pyridone catalyst.

graphic file with name d1ra04651a-u3.jpg
Entry R Conversiona
1 graphic file with name d1ra04651a-u4.jpg NO2 (10a) 23%
2 Cl (10b) 27%
3 OMe (10c) 34%
4 graphic file with name d1ra04651a-u5.jpg CF3 (11a) 32%
5 Cl (11b) 37%
6 OMe (11c) 34%
7 graphic file with name d1ra04651a-u6.jpg NO2 (12a) 42%
8 Cl (12b) 51%
9 OMe (12c) 41%
10 graphic file with name d1ra04651a-u7.jpg Cl (13a) 81%
11 Br (13b) 78%
12 I (13c) 86%
13 F (13d) 31%
14 CO2Me (13e) 50%
15 OMe (13f) 52%
16 CH3 (13g) 34%
17 graphic file with name d1ra04651a-u8.jpg Cl (14a) 58%
18 NO2 (14b) 22%
a

Conversion was calculated by 1H NMR spectroscopy.