| Methods |
Random allocation, double‐blind, placebo‐controlled design |
| Participants |
Adult eligible patients without history of seizures, who had meningioma (n=50), glioma (n=30), metastases (n=5) |
| Interventions |
Phenytoin: 15mg/kg intravenously before wound closure, then 5‐6 mg/kg/day intravenously, or placebo three times daily in the first three postoperative days |
| Outcomes |
Phenytoin was not more effective than placebo to prevent immediate and early postoperative seizures |
| Notes |
Study with no power to compare the subset with brain tumors |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
