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. 2022 Apr 11;13:845045. doi: 10.3389/fmicb.2022.845045

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Copyright © 2022 Yao, Zhu, Zou, Shenkutie, Hu, Qu, He and Leung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear comparison of pSZESBLEC201-1 and pSZESBLEC201-3 resistance regions with those of their closest related plasmids. (A) Comparison of pSZESBLEC201-1 MDR region with those of plasmids AR_0137, pEC958, AR_0014, uk_P46212, and pECO-824. (B) Comparison of the genetic environment surrounding bla_CTX-M in pSZESBLEC201-3, pSF-468-2, pCREC-591_1, pKHSB1, pTC_N40607, and pD3_B. Open reading frames are indicated with arrows. Homologous regions in different plasmids are linked with turquoise coloring, and degrees of homology are denoted by color depth. Red, bright green, gray, yellow, purple, and fuchsia represent genes associated with antibiotic resistance, catalytic activity, hypothetical proteins, regulation, transportation, and mobile genetic elements, respectively.