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. 2022 Apr 5;13:854285. doi: 10.3389/fgene.2022.854285

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Copyright © 2022 Zeng and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple mechanisms of ncRNAs regulating the differentiation of DMSCs. (A) Epigenetic regulation: miR-140-3p interacts with KMT5B, miR-153-3p interacts with KDM6A, and lncRNA SNHG1 interacts with EZH2, resulting in abnormal methylation. miR-22 interacts with HDAC6, and miR-17 interacts with HDAC9, resulting in abnormal acetylation. (B) gene transcription: lncRNA TUG1 interacts with RBP family member-Lin28A, affecting the transcriptional activation of downstream genes. (C) mRNA modulation: miRNA targets the 3′ untranslated region (UTR) of mRNA. (D) miRNA sponges: lncRNAs and circular RNAs target miRNAs. (E) signaling: all three ncRNAs can participate in signaling pathways.