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. 2022 Apr 5;13:854285. doi: 10.3389/fgene.2022.854285

FIGURE 3.

FIGURE 3

Overview of signaling pathways involved by ncRNAs during the differentiation of DMSCs. Red indicates signaling pathways associated with osteogenic differentiation. Purple indicates signaling pathways associated with odontogenic differentiation. Arrow indicates promotion and T indicates inhibition. Collectively, ncRNAs related to Wnt/β-catenin signaling pathway are miR-140-5p, miR-214, circRNA124534 and lncRNA POIR. MiR-20a-5p is involved in TGF-β, BMP and MAPK signaling pathway. NcRNAs associated with the BMP signaling pathway are lncPCAT1 and circRNA FAT1. LncRNA GAS5 is involved in BMP and MAPK signaling pathway. MiR-143-3p inhibits OPG-RANKL signaling pathway. NcRNAs related to the MAPK pathway are miR-143-5p, miR-218. MiR-875-5P is related to PDGF signaling pathway. There is a reciprocal positive feedback loop between miR-21 and STAT3 at low concentrations of TNF-α (1–10 ng/ml). MiR-140-5p inhibits the TLR-4 pathway under LPS stimulation. MiR-34a inhibits Notch signaling pathway.