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. 2022 Apr 5;13:854285. doi: 10.3389/fgene.2022.854285

FIGURE 5.

FIGURE 5

The regulatory mechanism of miR-21. Arrow indicates promotion and T indicates inhibition. (A) MiR-21 inhibits osteogenic differentiation by targeting Spry1 when under the TNF-α-induced inflammatory microenvironment. (B) MiR-21 inhibits osteogenic differentiation by targeting Smad5. (C) MiR-21 promotes osteogenic differentiation by targeting ACVR2B when exposed to mechanical stretch.