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. 2022 Apr 5;13:854285. doi: 10.3389/fgene.2022.854285

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Copyright © 2022 Zeng and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory mechanism of lncRNA H19. Arrow indicates promotion and T indicates inhibition. (A) H19 promotes osteo/odontogenic differentiation through H19/miR-141/SPAG9/MAPK axis. (B) H19 promotes odontoblastic differentiation through H19/miR-140-5p/BMP-2/FGF9 axis. (C) H19 epigenetically promotes odontoblastic differentiation by inhibiting DNMT3B-mediated methylation of DLX3. (D) H19 epigenetically promotes odontoblastic differentiation by repressing LATS1 through EZH2-induced trimethylation of H327me3.