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. 2022 Apr 5;13:854285. doi: 10.3389/fgene.2022.854285

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Copyright © 2022 Zeng and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory mechanism of lncRNA MEG3. Arrow indicates promotion and T indicates inhibition. (A) MEG3 leads to repression of BMP2 by competing with BMP2 mRNA for hnRNPs (an RNA-binding protein), which in turn inhibits osteogenic differentiation. (B) MEG3 promotes osteogenic differentiation through MEG3/miR-543/Smurf1 axis. (C) MEG3 promotes osteogenic differentiation through MEG3/miR-27a-3p/IGF1/PI3K/Akt axis. (D) MEG3 epigenetically regulating Wnt through the EZH2 regulation of H3K27me3 level on the Wnt genes promotors.