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. 2022 Apr 5;13:857440. doi: 10.3389/fimmu.2022.857440

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Copyright © 2022 Volkmann, Koopman, Mooij, Verschoor, Verstrepen, Bogers, Idorn, Paludan, Vang, Nielsen, Sander, Schmittwolf, Hochrein and Chaplin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutralization of SARS-CoV-2 variants of concern. (A) NHP were vaccinated as described in Figure 1 . Two weeks following the second administration, vaccine-induced antibodies were tested for their capacity to neutralize Wuhan-like SARS-CoV-2 (FR-4286) as well as the alpha (B.1.1.7), beta (B.1.351), and delta variants (B1.617.2) by PRNT. Filled circles represent PRNT50 titers of individual NHP, and columns depict the GMT of the group +/geometric standard deviation. Kruskal–Wallis test showed no statistically significant differences between the neutralization of Wuhan-like FR-4286 and the variants. (B) Ten human plasma samples positive for SARS-CoV-2 antibodies (human convalescents) were analyzed for comparison.