. 2021 Jul 21;11(41):25381–25421. doi: 10.1039/d1ra03091d

The effect of trisindolines 125–137 on seizures induced by MES in mice.

Trisindolines	R¹	R²	R³	R⁴	Time (s)
Trisindolines	R¹	R²	R³	R⁴	Flexion	Extensor	Clonus
125	H	H	H	Allyl	5.80 ± 0.20	48.00 ± 0.32	3.60 ± 0.20
126	5-NO₂	H	H	Allyl	4.80 ± 0.20	39.20 ± 0.40	3.40 ± 0.24
127	H	H	5-OMe	Allyl	4.80 ± 0.18	31.80 ± 0.40	3.20 ± 0.24
128	5-Cl	H	5-OMe	Allyl	5.80 ± 0.20	31.60 ± 0.37	3.40 ± 0.20
129	5-Br	H	5-OMe	Allyl	4.80 ± 0.20	39.20 ± 0.40	3.40 ± 0.24
130	H	CH₂CO₂Et	5-OMe	Allyl	4.80 ± 0.20	31.60 ± 0.37	3.40 ± 0.24
131	H	H	H	Cinnamyl	4.80 ± 0.20	39.60 ± 0.40	3.60 ± 0.20
132	H	H	5-Br	Prenyl	4.80 ± 0.20	39.60 ± 0.40	3.40 ± 0.24
133	H	Propargyl	5-Br	Prenyl	5.40 ± 0.24	31.60 ± 0.37	2.80 ± 0.24
134	H	H	H	Propargyl	4.80 ± 0.20	39.20 ± 0.40	3.20 ± 0.24
135	H	Bn	H	Propargyl	4.80 ± 0.18	39.20 ± 0.40	3.20 ± 0.24
136	H	Propargyl	H	Propargyl	5.40 ± 0.20	31.80 ± 0.32	3.60 ± 0.20
137	H	H	2-Me	Propargyl	5.40 ± 0.24	31.60 ± 0.37	2.80 ± 0.24
Phenytoin (reference standard)					5.60 ± 0.20	43.00 ± 0.40	3.40 ± 0.24