Fig. 6. Docking of compound 5b into SIRT-2 3D structure (pdb code: 4RMG). (A) Overlay of the top docked poses 5b (green and violet) and SirReal-2 (yellow) as a co-crystallized ligand into the Sirt-2 binding site where the Sirt-2 protein is represented as secondary structure displayed in a flat ribbon style (cartoon) colored in black-white; (B) labelling of the different binding pockets of Sirt-2 protein. The NAD⁺ co-factor (cyan) is displayed in stick.