Inhibitory activities of 5a–h against human SIRT2.
| Compound | % inhibition of SIRT2 | |
|---|---|---|
| 5 μm | 50 μm | |
| 5a | 19 ± 3 | 72 ± 3 |
| 5b | 26 ± 3 | 78 ± 3 |
| 5c | 17 ± 3 | 58 ± 3 |
| 5d | 18 ± 2 | 70 ± 3 |
| 5e | 24 ± 3 | 74 ± 2 |
| 5f | 20 ± 4 | 69 ± 3 |
| 5g | 19 ± 2 | 55 ± 1 |
| 5h | 22 ± 5 | 75 ± 3 |
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