Scope of the Passerini reaction carried out in U/CC DES with chiral heterogeneous catalyst 11.

Entry	R1 in RCOOH 12	R2 in RCHO 13	R3 in RNC 14	Time (h)	15	Yielda (%)	Eeb (%)
1	Ph; 12a	Ph; 13a	t-Bu; 14a	20	15a	87c	94.8
2	Ph; 12a	3-NO2C6H4; 13b	t-Bu; 14a	24	15b	93	96.4
3	Ph; 12a	4-MeOC6H4; 13c	t-Bu; 14a	20	15c	85	96.8
4	Ph; 12a	4-ClC6H4; 13d	t-Bu; 14a	22	15d	93	96.9
5	Ph; 12a	4-MeC6H4; 13e	t-Bu; 14a	24	15e	87	97.6
6	Ph; 12a	PhCH CH; 13f	t-Bu; 14a	28	15f	86	92.7
7	Ph; 12a	i-Pr; 13g	t-Bu; 14a	20	15g	87	95.5
8	4-NO2C6H4; 12b	Ph; 13a	t-Bu; 14a	24	15h	84	95.6
9	4-MeOC6H4; 12c	Ph; 13a	t-Bu; 14a	30	15i	87	95.9
10	4-ClC6H4; 12d	Ph; 13a	t-Bu; 14a	20	15j	90	96.8
11	Me; 12e	Ph; 13a	t-Bu; 14a	20	15k	86	96.5
12	PhCH2; 12f	Ph; 13a	t-Bu; 14a	22	15l	87	93.1
13	3-Pyridyl; 12g	4-ClC6H4; 13d	t-Bu; 14a	24	15m	78	96.5
14	Ph; 12a	Ph; 13a	2-Naphthyl; 14b	20	15n	87	98.4
15	Ph; 12a	4-ClC6H4; 13d	2-Naphthyl; 14b	20	15o	83	95.3
16	Me; 12e	3-NO2C6H4; 13b	2-Naphthyl; 14b	24	15p	84	97.6
17	Me; 12e	i-Pr; 13g	2-Naphthyl; 14b	22	15q	86	96.1

^aYields refer to pure and isolated 15. Times and yields refer to the reactions carried out with 1 mmol of 12a, 13a, 14a with chiral catalyst 11 (5% mol).

^bEnantiomeric excess was determined by chiral analyses on HPLC (ee).

^cThe same results were obtained using 10 mol% of catalyst 11.