Recovery and reuse of catalyst 11.
| Entry | Time (h) | Yield (%) of 15aa,b | Recovery of 11 | ee (%) in 15a |
|---|---|---|---|---|
| 1 | 24 | 87 | 0.06 gc | 94.8 |
| 2 | 24 | 85 | 0.06 gd | 95.0 |
| 3 | 24 | 87 | 0.06 ge | 93.2 |
| 4 | 28 | 88 | 0.05 gf | 93.1 |
| 5 | 28 | 84 | 0.05 g | 94.0 |
Yields refer to the pure and isolated product.
The reaction was performed at room temperature with 1 mmol of 12a, 13a, 14a and 5 mol% of 11.
Recovered 11 was used as a catalyst in entry 2.
Recovered 11 was used as a catalyst in entry 3.
Recovered 11 was used as a catalyst in entry 4.
Recovered 11 was used as a catalyst in entry 5.