. 2021 Jul 27;11(42):25867–25879. doi: 10.1039/d1ra03578a

Investigation of the optimal conditions for the coupling reaction of iodobenzene with PhB(OH)₂ in the presence of Cu–ninhydrin@GO–Ni MNPs.

Entry	Amount of catalyst (mg)	Solvent	Base	Temperature (°C)	Time (min)	Yield (%)
1	—	H₂O	Na₂CO₃	80	360	N.R.
2	20	H₂O	Na₂CO₃	80	120	93
3	30	H₂O	Na₂CO₃	80	50	97
4	40	H₂O	Na₂CO₃	80	40	96
5	30	PEG	Na₂CO₃	80	50	18
6	30	DMSO	Na₂CO₃	80	50	40
7	30	1,4-Dioxane	Na₂CO₃	80	50	Trace
8	30	DMF	Na₂CO₃	80	50	52
9	30	H₂O	KOH	80	50	48
10	30	H₂O	NaOCH₃	80	50	36
11	30	H₂O	Et₃N	80	50	58
12	30	H₂O	K₂CO₃	80	50	79
13	30	H₂O	Na₂CO₃	60	50	43

Investigation of the optimal conditions for the coupling reaction of iodobenzene with PhB(OH)2 in the presence of Cu–ninhydrin@GO–Ni MNPs.