Investigation of the optimal conditions for the synthesis of diphenyl ether in the presence of Cu–ninhydrin@GO–Ni MNPs.
Entry | Amount of catalyst (mg) | Solvent | Base | Temperature (°C) | Time (min) | Yield (%) |
---|---|---|---|---|---|---|
1 | — | DMSO | KOH | 130 | 300 | N.R. |
2 | 30 | DMSO | KOH | 130 | 120 | 98 |
3 | 20 | DMSO | KOH | 130 | 160 | 90 |
4 | 35 | DMSO | KOH | 130 | 105 | 93 |
5 | 30 | PEG | KOH | 130 | 120 | 48 |
6 | 30 | DMF | KOH | 130 | 120 | 72 |
7 | 30 | H2O | KOH | Reflux | 120 | 35 |
8 | 30 | DMSO | Na2CO3 | 130 | 120 | 20 |
9 | 30 | DMSO | NaHCO3 | 130 | 120 | 27 |
10 | 30 | DMSO | Et3N | 130 | 120 | 55 |
11 | 30 | DMSO | NaOCH3 | 130 | 120 | 31 |
12 | 30 | DMSO | NaOH | 130 | 120 | 74 |
13 | 30 | DMSO | KOH | 100 | 120 | 67 |