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Comparison between SARS-CoV-2 3CL protease (Mpro) from crystal structure 6Y2E (blue) and homology models of Mpro from four different bat coronaviruses, reported in Table 1. In Panel A, the pairwise RMSD matrix derived from the superposition of each bat coronavirus homology model to the template structure 6Y2E is reported. Panel B and C summarise the differences in the primary sequence between SARS-CoV-2 and bat coronaviruses Mpro.
