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. 2022 Apr 18;11(1):1115–1125. doi: 10.1080/22221751.2022.2059400

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The expression of islet function-related molecules was altered in patients with COVID-19. Immunochemical staining using antibodies against (A) CD36, (B) GLUT2, (C) IRS1, (D) IRS2, (E) PDX1 and (F) PPARG. In the patient with COVID-19 but without SARS-CoV-2 virus in the pancreas (SARS-CoV-2 negative), CD36, GLUT2, IRS2 and PDX1 were widely distributed in the pancreatic serous acinus, the duct (exocrine gland) and the islet (endocrine gland); PPARG was mainly in the islet; and IRS1 was barely detected. In the patient with COVID-19 accompanied by SARS-CoV-2 virus in the pancreas (SARS-CoV-2 positive), CD36, GLUT2, IRS1, IRS2, PDX1 and PPARG were mainly detected in the islets. CD36 was also present in the small vasculature of pancreatic interstitial tissue.