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. 2022 Apr 1;14(7):3049–3069. doi: 10.18632/aging.203988

Figure 7.

Figure 7

CircGSE1 regulates the angiogenic ability of MAECs via the NRP1. (A) Wound healing assay of OECs treated with vector, the OE-NRP1 or the OE-NRP1 + circGSE1 siRNA and YECs treated with the NC, NRP1-siRNA or NRP1-siRNA +OE-circGSE1. The graph indicates the quantification of the wounded area 24 hours after scratching (n=3, scale bar: 200 μm). (B) Tube formation assay of OECs treated with the vector, the OE-NRP1 or the OE-NRP1 + circGSE1 siRNA and YECs treated with the NC, NRP1-siRNA or NRP1-siRNA +OE-circGSE1 (n=3, scale bar, 200 μm). (C) Migration assay of OECs treated with the vector, the OE-NRP1 or the OE-NRP1 + circGSE1 siRNA and YECs treated with the NC, NRP1-siRNA or NRP1-siRNA +OE-circGSE1 (n=5, scale bar, 200 μm). (D) EdU assay of OECs treated with the vector, the OE-NRP1 or the OE-NRP1 + circGSE1 siRNA and YECs treated with the NC, NRP1-siRNA or NRP1-siRNA +OE-circGSE1 (n=5, scale bar, 200 μm). (The data are expressed as the mean ± SD, *P < 0.05 **P < 0.01 versus the negative control).