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. 2022 Apr 12;14(7):3191–3202. doi: 10.18632/aging.204007

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Copyright: © 2022 Yue et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Effects of Epitalon on the integrity of postovulatory aged oocytes and after parthenogenetic activation. (A) Representative images of fragmented oocytes in the Control, Aged and 0.1mM Epitalon-treated groups. (B) The rates of oocyte fragmentation were recorded in the Control, Aged and Epitalon-treated oocytes. Epitalon was supplemented to the culture medium with a concentration of 0.1mM, 0.25mM, 0.5mM, 1mM, or 2mM. (C) Representative images of 2-cell embryos from the Control, Aged and 0.1mM Epitalon-treated groups. (D) The rates of fragmentation after parthenogenetic activation were recorded in the Control, Aged, and 0.1mM Epitalon-treated oocytes. Data from more than 30 oocytes were analyzed for each group. Significant difference between the Aged and 0.1mM Epitalon groups was observed (p < 0.01). Data are expressed as mean ± SEM of at least three independent experiments. Scale bar: 100 μm. PA, parthenogenetic activation.