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. 2021 Jul 14;1:14. doi: 10.1038/s43856-021-00013-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative concept patches for each of the six concepts used for TCAV analysis. b TCAV scores for positive (blue) and negative (red) biomarker status for each of the three biomarkers. Error bars are 95% confidence intervals over 20 trials using 500 class-of-interest patches, 500 random patches, and 100 concept patches per trial. Higher scores indicate stronger association of the concept with the model’s representation of that biomarker status. Detailed TCAV scores are provided in Supplementary Table 3 and Supplementary Data 2. TIL tumor infiltrating lymphocytes, ER Estrogen Receptor, PR Progesterone Receptor, HER2 human epidermal growth factor receptor 2, DCIS Ductal Carcinoma In Situ.