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. 2022 Mar 21;154(9):e202112994. doi: 10.1085/jgp.202112994

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© 2022 Barclay and Launikonis

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Figure 12. — Modeling MH-susceptible fibers. Experimental data (symbols: filled circles, with tetracaine; open circles, without tetracaine) from human muscle fibers containing an MH causative mutation of the RYRs. Curves (blue, with tetracaine; red, without tetracaine) show the best fit of the model to the experimental data. Note, point marked with an asterisk was omitted from the analysis (for explanation, see Results). The best-fit value of $k_{L e a k}^{R y R}$ was 0.08 s⁻¹.