Table 1.
Current activation properties of CaV1.1a and CaV1.1e expressed in HEK-STAC3 and HEK-TetOn-STAC3 cells
| Property | HEK-STAC3 | HEK-TetOn-STAC3 | ||||
|---|---|---|---|---|---|---|
| CaV1.1a | CaV1.1e | P value (t test) | CaV1.1a | CaV1.1e | P value (t test) | |
| Ipeak (pA/pF) | −19.8 ± 2.7 | −19.5 ± 2.4 | 0.94 | −18.2 ± 3.1 | −21.3 ± 4.5 | 0.56 |
| V1/2 activation (mV) | 24.4 ± 0.7 | 4.0 ± 1.0 | **** | 24.1 ± 1.4 | 3.0 ± 1.5 | **** |
| k activation (mV) | 8.1 ± 0.4 | 7.1 ± 0.2 | 0.03* | 7.0 ± 0.5 | 5.3 ± 0.3 | 0.011* |
| Vrev (mV) | 86.3 ± 1.2 | 75.3 ± 1.1 | **** | 81.2 ± 1.7 | 72.8 ± 1.6 | 0.0013** |
| Time to peak (ms) | 173.1 ± 10.8 | 162.6 ± 12.0 | 0.52 | 198.3 ± 20.4 | 184.1 ± 14.3 | 0.59 |
| n | 15 | 15 | 19 | 15 | ||
Data are expressed as mean values ± SEM. Statistically significant: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.