Table 2.
Current properties (activation and inactivation) of CaV1.1a and CaV1.1e in the presence and absence of γ1
| Property | CaV1.1a | CaV1.1a + γ1 | P value | CaV1.1e | CaV1.1e + γ1 | P value |
|---|---|---|---|---|---|---|
| Ipeak (pA/pF) | −18.9 ± 2.9 | −7.8 ± 1.2 | 0.012* | −24.1 ± 4.0 | −26.1 ± 2.7 | 0.69 |
| V1/2 activation (mV) | 26.3 ± 1.0 | 29.4 ± 2.0 | 0.14 | 3.9 ± 1.1 | 4.5 ± 0.9 | 0.68 |
| k activation (mV) | 6.8 ± 0.2 | 8.3 ± 0.8 | 0.03* | 5.1 ± 0.3 | 5.2 ± 0.2 | 0.70 |
| Vrev (mV) | 83.4 ± 1.1 | 78.6 ± 2.8 | 0.07 | 75.7 ± 2.0 | 76.0 ± 1.3 | 0.90 |
| Time to peak (ms) | 150.1 ± 18.0 | 102.9 ± 15.0 | 0.08 | 104.4 ± 11.0 | 97.1 ± 13.3 | 0.67 |
| τmono activation (ms) | 35.1 ± 3.0 | 32.9 ± 2.9 | 0.65 | 30.3 ± 5.5 | 23.7 ± 4.0 | 0.19 |
| τslow activation (ms) | 107.4 ± 39.9 | 79.6 ± 21.2 | 0.53 | |||
| Aslow activation (%) | 18.7 ± 6.9 | 31.0 ± 11.8 | 0.41 | |||
| τfast activation (ms) | 26.4 ± 6.1 | 17.1 ± 4.4 | 0.23 | |||
| Afast activation (%) | 81.3 ± 6.9 | 69.0 ± 11.8 | 0.41 | |||
| n (activation) | 19 | 10 | 12 | 13 | ||
| V1/2 inactivation (mV) | −16.9 ± 2.6 | −31.0 ± 5.3 | 0.04* | −28.6 ± 1.7 | −42.3 ± 1.9 | *** |
| Iresidual (%) | 18.7 ± 7.4 | 14.7 ± 4.6 | 0.66 | 9.8 ± 3.1 | 3.9 ± 1.3 | 0.13 |
| k inactivation (mV) | 8.1 ± 0.4 | 7.9 ± 0.9 | 0.89 | 7.0 ± 0.9 | 7.3 ± 0.3 | 0.79 |
| τmono inactivation (ms) | 2,062.4 ± 525.5 | 1,389.5 ± 251.5 | 0.32 | 2,159.8 ± 278.5 | 1,453.2 ± 230.3 | 0.15 |
| n (inactivation) | 6 | 6 | 7 | 6 |
Data are expressed as mean values ± SEM. Statistically significant: *, P < 0.05; ***, P < 0.001.