Figure 3.

Amino acid substitutions in the spike protein identified in the UK dataset (referred to as ‘Escape mutations’) that have been associated with weaker neutralisation of the virus by convalescent or post-vaccination plasma/serum or spike-specific monoclonal antibodies (mAbs) or that have been observed to emerge upon exposure to either mAbs or plasma in laboratory experiments.

*High confidence (red) refers to an antigenic role supported by multiple studies, including at least one that reports an effect observed with (post-infection serum) convalescent plasma; ‘medium’ (orange), if the antigenic role is supported by multiple studies; and ‘low’ (yellow), when the mutation is supported by a single study. The boxes above the table enable filtering by multiple criteria.