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. 2022 Apr 18;14(1):2057778. doi: 10.1080/19490976.2022.2057778

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Parasutterella in relation to other gut microbiome species in human obesity. (a) LogFold Changes of differentially abundant microbes in human obesity in the FoCus cohort. Comparison was made between the normal weight group (BMI < 25) and the obese group (BMI > 30, without T2D). Parasutterella sp. is among the top 20 (=3%) differentially abundant species out of 665 species tested. Plot shows the top 50 differentially expressed species, eight species could not be assigned to a genus (marked NA in the plot). Parasutterella sp. is placed 18th among the top 50. (b) Composition plots of probands with high and low (threshold <10 counts) Parasutterella sp. (c) ROC curves for prediction models (random forests) of BMI and T2D groups by Akkermansia (green, AUC: 0.22–0.28) and Parasutterella (purple, AUC: 0.83–0.87) abundance. Comparisons were made between the normal weight group and the (1) obese group without diabetes, (2) obese group with diabetes, and (3) the overweight group according to Table 1. Classifier performance was tested using bootstrapping of AUC results and revealed significantly better performance of Parasutterella compared to Akkermansia in all comparison groups (P = 5.2e-191;-2.8e-185).