Figure 6.

Circ_0007059 is a ceRNA that sponges miR-378 and miR-383. (a) Bioinformatics analyses indicated that circ_0007059 contains a binding site for miR-378 and miR-383. (b, c) DLRA was conducted through co-transfection of a luciferase reporter with WT or MU circ_0007059-binding sites with miR-378 and miR-383 mimics into cardiomyocytes. (d, e) qPCR quantification of miR-378 and miR-383 expression in the infarcted hearts of MI mice. (f, g) Cardiomyocytes were infected with lentiviral-si-circ_0007059/siNC for 1 d and subsequently exposed to H₂O₂ (0.1 mM) for 1 d. qPCR was used to quantify miR-378 and miR-383 expression. *P < 0.05 versus the CG; ^#P < 0.05 versus the H₂O₂ group.