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. 2022 Apr 23;11(1):2067944. doi: 10.1080/2162402X.2022.2067944

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Complementary studies for total protein concentration in patients plasma-circulating sEVs showing a correlation between a high protein amount and a worse prognosis. a. Survival analysis showing the cumulative survival probability in patients with previously untreated metastatic lung cancer according to the protein concentration in plasma-circulating sEVs (taking the median value of the group as reference). b. Survival analysis showing the cumulative survival probability in patients with previously untreated metastatic melanoma according to the protein concentration in plasma-circulating sEVs (taking the median value of the group as reference). Differences were assessed using the Log-Rank test. c. Analysis of protein concentration in circulating sEVs regarding the type of progression experienced in patients with metastatic breast cancer and known central nervous system (CNS) involvement: at CNS only or at CNS and other locations. * p value 0.02. ns: not significant.