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. 2021 Jun 8;18(3):518–539. doi: 10.1080/15548627.2021.1936356

Figure 9.

Figure 9.

Effect of G. cambogia extract on the identified targets in HFD-induced adipose tissues. (A and B) Effect of G. cambogia extract on phospho- and total-RPS6KA1, phospho- and total-STAT3, LC3, SQSTM1, KLF3, CEBPA and PPARG expression of eWAT and iWAT in ND-fed, HFD-fed and HFD-fed mice administered a high dose of G. cambogia extract (400 mg/kg) (n = 6 per group). (C) Correlations between phospho-RPS6KA1, phospho-STAT3 and KLF3 protein expression in eWAT and iWAT (n = 6 per group). Each point represents one sample. (D and E) Immunofluorescence analysis of phospho-RPS6KA1, phospho-STAT3 and KLF3 expression in eWAT and iWAT (n = 4 per group). Nuclei were stained with DAPI (blue), and white arrows indicate phospho-RPS6KA1, phospho-STAT3 and KLF3 colocalization with DAPI. Scale bars, 50 μm. **p < 0.01 vs. ND-fed mice, #p < 0.05 and ##p < 0.01 vs. HFD-fed mice. The data are the mean ± S.D.