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. 2022 Apr 18;23(1):328–335. doi: 10.1080/15384047.2022.2058862

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Curcumin activated caspase-1 and promoted GSDMD cleavage in leukemia cells.

(a) U937 cells treated with different concentration of curcumin (0, 5, 10, and 20 µM) and detected the cleavage of GSDMD and activation of caspase-1 by western blot. (b) The expression plasmids of GSDMD-F and GSDMD-N fused with EGFP were constructed. (c) HEK-293 T cells were transfected with GSDMD plasmids and analyzed the cleavage effect of GSDMD after treated with curcumin for 24 h by detecting with GFP and GSDMD antibody. (d) Expression of GSDMD-affected morphology of 293 T cells after treating with curcumin.