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. 2022 Apr 18;23(1):328–335. doi: 10.1080/15384047.2022.2058862

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Overexpression of GSDMD enhance anti-leukemia effect of curcumin.

(a) Western blot array analyzed the expression of GSDMD in different AML cell lines and cleavage of GSDMD after treating with curcumin. (b) DOX induced expression of GSDMD in a stable GSDMD-K562 cell line. (c) CCK-8 array analyzed growth curves of the stable K562 cell lines after treated with curcumin at 24, 48, and 72 h. (d) Cell morphology changes was analyzed in the table K562 cell lines after treated with curcumin. (d) The apoptosis was analyzed in the table K562 cell lines after treated with curcumin.