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Knock-down GSDMD inhibits curcumin-induced death of U937 cells.
(a) GSDMD-specific shRNA or nonspecific (GFP) shRNA lentivirals infected U937 cells for 120 h, and the knockdown efficiency of endogenous GSDMD was analyzed by western blot. (b) CCK-8 array analyzed affection of knocking-down GSDMD on the growth inhibition of U937 cells after treating with curcumin for 24 h. (c) Schema of the mechanism for curcumin induces pyroptosis in AML cells.
