1 Event‐free Survival ‐ all studies |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
2 Event‐free Survival ‐ different high‐dose settings |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
2.1 High‐dose sequential therapy without induction |
2 |
|
Hazard Ratio (Fixed, 95% CI) |
0.75 [0.51, 1.12] |
2.2 Abbreviated standard induction |
7 |
|
Hazard Ratio (Fixed, 95% CI) |
0.97 [0.84, 1.13] |
2.3 Full standard induction |
3 |
|
Hazard Ratio (Fixed, 95% CI) |
0.74 [0.50, 1.10] |
3 Event‐free Survival ‐ patients' status at randomisation |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
3.1 Patients irrespectively of disease status |
10 |
|
Hazard Ratio (Fixed, 95% CI) |
0.91 [0.79, 1.04] |
3.2 Patients in PR |
2 |
|
Hazard Ratio (Fixed, 95% CI) |
1.08 [0.67, 1.73] |
4 Event‐free Survival ‐ methodological quality |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
4.1 Sufficient method |
11 |
|
Hazard Ratio (Fixed, 95% CI) |
0.95 [0.83, 1.08] |
4.2 Insufficient or unknown method |
1 |
|
Hazard Ratio (Fixed, 95% CI) |
0.36 [0.18, 0.72] |
5 Event‐free Survival ‐ study size |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
5.1 > 100 patients |
7 |
|
Hazard Ratio (Fixed, 95% CI) |
0.96 [0.83, 1.11] |
5.2 < 100 patients |
5 |
|
Hazard Ratio (Fixed, 95% CI) |
0.74 [0.55, 1.01] |
6 Event‐free Survival ‐ protocol adherence to HDT |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
6.1 > 70% |
7 |
|
Hazard Ratio (Fixed, 95% CI) |
1.03 [0.86, 1.22] |
6.2 < 70% |
5 |
|
Hazard Ratio (Fixed, 95% CI) |
0.79 [0.65, 0.97] |
7 Event‐free Survival ‐ bone marrow involvement |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
7.1 >20% |
5 |
|
Hazard Ratio (Fixed, 95% CI) |
0.98 [0.82, 1.18] |
7.2 <20% |
7 |
|
Hazard Ratio (Fixed, 95% CI) |
0.85 [0.70, 1.03] |
8 Event‐free Survival ‐ % of patients with DLCL (wide def.) |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
8.1 > 80% |
7 |
|
Hazard Ratio (Fixed, 95% CI) |
0.80 [0.65, 0.97] |
8.2 < 80% |
5 |
|
Hazard Ratio (Fixed, 95% CI) |
1.02 [0.86, 1.21] |
9 Event‐free Survival ‐ % of patients with DLCL (narrow def.) |
12 |
|
Hazard Ratio (Fixed, 95% CI) |
0.92 [0.80, 1.05] |
9.1 > 70% |
6 |
|
Hazard Ratio (Fixed, 95% CI) |
0.72 [0.58, 0.89] |
9.2 < 70% |
6 |
|
Hazard Ratio (Fixed, 95% CI) |
1.06 [0.90, 1.26] |
10 Event‐free Survival ‐ IPI groups |
11 |
|
Hazard Ratio (Fixed, 95% CI) |
0.96 [0.84, 1.10] |
10.1 IPI ‐ low and low‐intermediate risk |
6 |
|
Hazard Ratio (Fixed, 95% CI) |
1.02 [0.75, 1.37] |
10.2 IPI ‐ high‐intermediate and high risk |
11 |
|
Hazard Ratio (Fixed, 95% CI) |
0.95 [0.81, 1.11] |