Comparison 6. Treatment related mortality / Mortality during treatment (TRM/MDT).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 TRM/MDT ‐ all studies	14	2555	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.93, 1.79]
1.1 TRM	3	807	Risk Ratio (M‐H, Fixed, 95% CI)	3.05 [0.74, 12.64]
1.2 MDT	9	1427	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.84, 1.70]
1.3 Others	2	321	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [0.45, 4.21]
2 TRM/MDT ‐ different high‐dose settings	14	2555	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.93, 1.79]
2.1 High‐dose sequential therapy without induction	2	224	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.40, 4.04]
2.2 Abbreviated standard induction therapy	8	1569	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.88, 1.83]
2.3 Full standard induction therapy	4	762	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [0.57, 3.67]
3 TRM/MDT ‐ patients' status at randomisation	14	2555	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.93, 1.79]
3.1 Patients irrespectively of disease status	11	1896	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.89, 1.74]
3.2 Patients in CR or PR	3	659	Risk Ratio (M‐H, Fixed, 95% CI)	3.07 [0.49, 19.20]
4 TRM/MDT ‐ methodological quality	14	2555	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.93, 1.79]
4.1 Sufficient method	12	2234	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.91, 1.81]
4.2 Insufficient or unknown method	2	321	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [0.45, 4.21]
5 TRM/MDT ‐ study size	13	2014	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.92, 1.78]
5.1 >100 pts.	8	1696	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [0.89, 1.99]
5.2 <100 pts.	5	318	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.66, 2.05]
6 TRM/MDT ‐ protocol adherence to HDT	12	1791	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.91, 1.79]
6.1 >70%	7	1033	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.58, 1.70]
6.2 <70%	5	758	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.99, 2.34]
7 TRM/MDT ‐ preparative HDT regimen	13	2014	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.92, 1.78]
7.1 BEAC	3	393	Risk Ratio (M‐H, Fixed, 95% CI)	2.48 [0.49, 12.58]
7.2 BEAM	6	1280	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.80, 1.66]
7.3 TBI	3	215	Risk Ratio (M‐H, Fixed, 95% CI)	2.02 [0.75, 5.43]
7.4 Others	1	126	Risk Ratio (M‐H, Fixed, 95% CI)	1.1 [0.16, 7.57]
8 TRM/MDT ‐ bone marrow involvement	12	1791	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.91, 1.79]
8.1 >20% of pts.	5	891	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.58, 1.89]
8.2 <20% of pts.	7	900	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [0.94, 2.13]
9 TRM/MDT ‐ % of patients with DLCL (wide def.)	12	1791	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.91, 1.79]
9.1 >80%	8	1008	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [0.96, 2.10]
9.2 <80%	4	783	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.50, 1.89]
10 TRM/MDT ‐ % of patients with DLCL (narrow def.)	12	1791	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.91, 1.79]
10.1 >70%	6	673	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.73, 2.10]
10.2 <70%	6	1118	Risk Ratio (M‐H, Fixed, 95% CI)	1.30 [0.84, 2.01]