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. 2022 Mar 18;10:817180. doi: 10.3389/fcell.2022.817180

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Copyright © 2022 Comariţa, Vîlcu, Constantin, Procopciuc, Safciuc, Alexandru, Dragan, Nemecz, Filippi, Chiţoiu, Gherghiceanu and Georgescu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of experimental animal models obtained for a period of 4 months. Golden Syrian hamsters (67 males and 3 months old) were divided into seven experimental groups: (1) control (C group); (2) simultaneously hypertensive–hyperlipidemic (HH group); (3,4) HH hamsters with retro-orbital sinus injection containing 100 μg/ml EVs from both ADSCs and BM-MSCs (HH-EVs (ADSCs) group and HH-EVs (MSCs) group)); (5,6) HH hamsters with retro-orbital sinus injection containing 100 μg/ml EVs (from ADSCs or BM-MSCs) transfected with 100 nM Smad2/3 siRNA (HH-EVs (ADSCs)+Smad2/3 siRNA group and HH-EVs (MSCs)+ Smad2/3 siRNA group); (7) HH hamsters with subcutaneous injection containing 100 nM Smad2/3 siRNA (HH-Smad2/3 siRNA group). The HH group was obtained by combining the atherogenic and high-salt diet.