Effect of the aqueous extract and nanoparticles of M. zapota leaves on the latency time (seconds) in FCA-induced arthritic ratsa.
| Latency time (secs) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Groups | Day 0 | Day 4 | Day 8 | Day 12 | Day 16 | Day 20 | Day 24 | Day 28 |
| Normal control | 8.5 ± 1.29 | 8.9 ± 0.85 | 8.5 ± 1.29 | 8.3 ± 0.96 | 8.8 ± 0.96 | 8.62 ± 1.15 | 8.8 ± 0.96 | 9.0 ± 0.81 |
| Arthritic control | 8.9 ± 0.95 | 7.6 ± 1.25 | 7.2 ± 0.56 | 6.4 ± 0.48*a | 6.2 ± 0.76*a | 6.0 ± 0.78*a | 5.0 ± 1.63*a | 4.5 ± 1.29*a |
| Positive control | 8.6 ± 0.95 | 8.3 ± 0.96 | 7.5 ± 1.29 | 6.3 ± 0.96 | 12.3 ± 0.96* | 14.5 ± 1.29* | 17.0 ± 1.83* | 20.3 ± 2.22* |
| AEMZ (200 mg kg−1) | 8.0 ± 0.82 | 7.3 ± 0.96 | 6.4 ± 0.85 | 5.7 ± 0.57 | 8.05 ± 1.02 | 9.9 ± 0.85* | 11.6 ± 0.94* | 13.0 ± 0.91* |
| AEMZ (400 mg kg−1) | 8.0 ± 0.82 | 7.3 ± 1.71 | 6.5 ± 6.50 | 5.3 ± 0.96 | 7.88 ± 1.93 | 10.1 ± 1.65* | 12.5 ± 1.29* | 15.5 ± 1.29* |
| NPMZ (5 mg kg−1) | 9.0 ± 0.69 | 7.5 ± 1.29 | 6.5 ± 1.29 | 5.9 ± 0.87 | 10.0 ± 0.82* | 15.0 ± 1.83* | 17.1 ± 2.09* | 17.3 ± 2.22* |
a
Statistical analysis of results was conducted between the arthritic group and the control group using the unpaired t-test. Comparison among the arthritic group and all other groups was conducted using one way ANOVA, followed by Dunette's test. Values are expressed in mean ± SD (n = 4). (*ap < 0.05) represents significance.