Fig. 4. Mode of action of Avigan-loaded nano-emulsions towards SARS-CoV-2 outside host cell (I) interfere with the virion envelope composition or mask the virus (SARS-CoV-2) building, so prevents SARS-CoV-2 adsorption and invasion into the host cells by Avigan-loaded nano-emulsion and (II) actions inside host cell including, interference with the viral enzyme (RNA-dependent RNA polymerase).