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Kinetic properties of DHPS enzymes from S. pneumoniae strains with different repeats of amino acids
| Source of DHPS | Amino acid repeat | Mean Km ± SD (μM) for:
|
Mean Ki for STZa ± SD (μM) | |
|---|---|---|---|---|
| p-AB | Pteridine | |||
| WA-5, Sulr | Ile66-Glu67 | 2.0 ± 0.18 | 5.3 ± 1.6 | 18 ± 4 |
| WA-5 Mut, Suls | None | 0.8 ± 0.12 | 5.5 ± 1.0 | 0.43 ± 0.16 |
| CP1015, Suls | None | 0.73 ± 0.04 | 4.5 ± 0.4 | 0.54 ± 0.19 |
| Pn93/720, Sulr | Ser61 | 2.6 ± 0.23 | 5.5 ± 1.0 | 7.5 ± 1.20 |
| J94/76, Sulr | Ser61-Ser62 | 1.3 ± 0.22 | 9.7 ± 0.5 | 12.3 ± 2.1 |
STZ, sulfathiazole.
