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. 2022 Apr 25;17(4):e0267241. doi: 10.1371/journal.pone.0267241

Table 2. IVF versus ICSI uncorrected values.

Morphokinetic parameters IVF ICSI Univariate p value Multivariate analysis
mean ± SD n mean ± SD n p value OR [95%CI]
tPNf 25.9 ± 10.2 182 23.2 ± 5.9 189 0.005 0.569 1.069 [0.849–1.348]
t2 29.3 ± 10.4 181 25.9 ± 5.1 187 <0.001 0.033 1.282 [1.020–1.612]
t3 38.4 ± 10.0 180 35.4 ± 6.2 187 0.001 0.773 0.986 [0.894–1.086]
t4 40.2 ± 7.2 176 37.7 ± 6.7 182 0.003 0.302 0.952 [0.867–1.045]
t5 50.4 ± 10.7 175 46.9 ± 7.9 177 0.001 0.264 1.035 [0.974–1.100]
t6 53.0 ± 10.2 169 50.9 ± 8.5 174 0.096 0.193 0.946 [0.870–1.028]
t7 56.0 ± 9.7 163 54.1 ± 9.9 170 0.177 0.287 1.034 [0.972–1.100]
t8 60.8 ± 11.9 158 58.8 ± 12.5 165 0.407
t9 70.2 ± 10.3 138 68.1 ± 11.2 149 0.437
tSC 80.6 ± 10.9 152 77.7 ± 12.6 160 0.327
tM 90.3 ± 10.0 147 87.4 ± 11.1 151 0.352
tSB 98.0 ± 9.0 146 97.2 ± 10.7 149 0.496
tB 112.3 ± 10.7 131 109.5 ± 10.8 128 0.437
tEB 121.1 ± 10.2 99 119.4 ± 11.6 105 0.921
Blast1.tB-tSB 15.3 ± 6.8 130 14.9 ± 6.9 126 0.969
Blast.tSB-t2 70.8 ± 8.2 146 72.5 ± 9.7 149 0.004 0.064 0.970 [0.940–1.002]
cc2.t3-t2 9.1 ± 4.8 180 9.7 ± 4.2 187 0.495
cc3.t5-t3 13.0 ± 8.8 175 12.0 ± 5.8 177 0.305
s2.t4-t3 2.7 ± 4.9 176 2.4 ± 3.9 182 0.977
s3.t8-t5 11.7 ± 9.9 158 11.6 ± 10.7 165 0.434

Comparison of time lapse parameters (hours) between sibling oocytes inseminated by IVF and ICSI. SD: standard deviation, n: number, OR: odds ratio, CI: confidence interval.