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. Author manuscript; available in PMC: 2023 Apr 21.
Published in final edited form as: Mol Cell. 2022 Apr 21;82(8):1477–1491. doi: 10.1016/j.molcel.2022.03.025

Figure 1. ERQC is defined by the partitioning of proteins between ER protein folding/trafficking and degradation pathway.

Figure 1.

Secretory proteins are co-translationally imported into the ER through the translocon channel where they immediately engage ER chaperones and folding factors. Through these interactions, proteins are assisted in attaining their folded conformation, allowing them to be trafficked to the Golgi and subsequently to downstream secretory environments such as the extracellular space. Proteins unable to attain a folded conformation within the ER are instead recognized by degradation factors and directed towards proteasomal or lysosomal degradation through ERAD or ER-phagy, respectively. Created with BioRender.com.